MONDAY, June 27, 2022 (HealthDay News) — Several environmental factors show associations with mortality when adjusting for individual risk factors, according to a study published online June 24 in PLOS ONE.
Michael B. Hadley, MD, of the Icahn School of Medicine at Mount Sinai in New York, and colleagues developed a spatial survival model to estimate associations between environmental exposures (ambient air pollution by fine particles; household fuel use and ventilation; proximity to traffic; distance to percutaneous coronary intervention center; socio-economic environment; population density; local land use; and exposure to nocturnal light) and all-cause and cardiovascular mortality in 50,045 people living in a low-income region in Iran.
Researchers found that ambient fine particulate air pollution predicted all-cause mortality (hazard ratio [HR], 1.20; 95% confidence interval [CI], 1.07 to 1.36) and cardiovascular mortality (RR, 1.17; 95% CI, 0.98 to 1.39). Similarly, the use of biofuels without a chimney predicted all-cause mortality (HR, 1.23; 95% CI, 0.99 to 1.53) and cardiovascular mortality (HR, 1.36; 95% CI %, 0.99 to 1.87), as did the use of kerosene without a chimney (all-cause mortality: HR, 1.09; 95% CI, 0.97 to 1.23; cardiovascular mortality: HR, 1 .19; 95% CI, 1.01 to 1.41). The multivariate model effectively predicted both all-cause mortality (area under the curve, 0.76) and cardiovascular mortality (area under the curve, 0.81) in a validation cohort.
“Mortality attributable to environmental factors represents a critical opportunity for targeted policies and programs,” the authors write.